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1 to 5 of 5 Results
DLC1 knockdown in EMT in MCF10A cells
Mar 21, 2025 - Mathematical modeling and simulation of cellular systems
Höpfl, Sebastian; Radde, Nicole, 2025, "DLC1 knockdown in EMT in MCF10A cells", https://doi.org/10.18419/DARUS-4240, DaRUS, V1
MCF10A cells were seeded and transfected with two siRNAs targeting dlc1 and one control siRNA. 10 ng/ml TGFb was used to induce EMT and added 24 h after the transfection. For modeling, the CBS model of Tian et al. (2003) was extended by DLC1. The model was calibrated using the MCF10A data after 5 days under the control and dlc1 targeted siRNA. The...
Modeling the sphingolipid rheostat under wild-type and hypomorph Hai1a
Modeling the sphingolipid rheostat under wild-type and hypomorph Hai1a
Apr 11, 2024
Höpfl, Sebastian, 2024, "Modeling the sphingolipid rheostat under wild-type and hypomorph Hai1a", https://doi.org/10.18419/DARUS-3838, DaRUS, V1, UNF:6:az4wbAbWWcIbbLxQh/QPXA== [fileUNF]
This dataset contains the proposed sphingolipid rheostat model with mass-action kinetics and a proposed negative feedback from ceramide to its synthesis from Sphinganine. The model is written in the Systems Biology Markup Language (SBML) and with the experimental data, experimental conditions, parameters, and observables part of the PEtab paramter...
MRI based perfusion of rats with 60% PVL
Apr 9, 2024 - Mathematical modeling and simulation of cellular systems
Herrmann, Karl-Heinz; Zhao, Wan-Ting; Höpfl, Sebastian; Reichenbach, Jürgen R., 2024, "MRI based perfusion of rats with 60% PVL", https://doi.org/10.18419/DARUS-3878, DaRUS, V1, UNF:6:sQocf/P7vdAmWMQR6rEEJw== [fileUNF]
The study investigates in vivo liver perfusion in rats. Perfusion of ligated and non-ligated liver lobes of 25 rats was monitored via MRI. Rats were subjected to 60% Portal Vein Ligation (PVL). Experimentally, the left stem of the portal vein (supplying Left Median (LML) and Left Lateral Lobe (LLL)) and the right stem to the Right Lobe (RL) were li...
Bayesian Modeling of Time Series Data (BayModTS)
Apr 8, 2024 - Mathematical modeling and simulation of cellular systems
Höpfl, Sebastian, 2024, "Bayesian Modeling of Time Series Data (BayModTS)", https://doi.org/10.18419/DARUS-3876, DaRUS, V1
BayModTS is a FAIR workflow for processing highly variable and sparse data. The code and results of the examples in the BayModTS paper are stored in this repository. A maintained version of BayModTS that can be applied to your personal applications can be found on Git Hub.
Percentile Intervals in Bayesian Inference are Overconfident
Mar 19, 2024
Höpfl, Sebastian, 2024, "Percentile Intervals in Bayesian Inference are Overconfident", https://doi.org/10.18419/DARUS-4068, DaRUS, V1
This dataset demonstrates the difference in calculating percentile Intervals as approximation for Highest Density Intervals (HDI) vs. Highest Posterior Density (HPD). This is demonstrated with extended partial liver resection data (ZeLeR-study, ethical vote: 2018-1246-Material). The data includes Computed Tomography (CT) liver volume measurements o...
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