Institute of Biochemical Engineering

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11 to 20 of 4,923 Results

Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells" Sep 24, 2026 - Mammalian Cell Culture Barczyk, Jonas; Lopez medina, Barbara; Teleki, Attila; Satzer, Peter; Rautenbach, Ryan; Schlüter, Michael; Takors, Ralf, 2026, "Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells"", https://doi.org/10.18419/DARUS-6466, DaRUS, V1, UNF:6:lArxh/lys3TNx0/WEN5Rtg== [fileUNF] Raw data for the manuscript “Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells”. The work explores two approaches of prolonged mixing time in laboratory-scale vessels without changing the power input. Experiments in 3 liter bioreactors were performed with NISTCHO...
All Data.xlsx Sep 24, 2026 - Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells" MS Excel Spreadsheet - 40.9 KB - MD5: dc3de263c77dcf507c4e83522aba750c All Data Excel format: This MS Excel spreadsheet table contains all the tables described above just in xlsx format. Figure1 is missing because it is just an image and contains no scientific data.
Figure10.csv Sep 24, 2026 - Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells" Comma Separated Values - 2.5 KB - MD5: 3f1212a95ab4b7b7c9b40a2418f48ff1 CSV file for Figure10: Intracellular concentrations of key metabolites and amino acids are visible here with corresponding process time point of 5, 7, 9 and 11 days. Intracellular metabolite concentrations were determined in fmol/cell with HPLC coupled to a triple quadrupole mass spectrometer. Detected masses were confirmed with internal standards...
Figure2.csv Sep 24, 2026 - Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells" Comma Separated Values - 153 B - MD5: 265e1264a8894320fc7a616663beafa3 Bioreactor mixing times of three bioreactor systems. The single multi-compartment bioreactor (SMCB), the perfect Downscale system (pDs) and the reference. All bioreactors were filled with 3.2 liters of 0.9% NaCl solution. The time in seconds was determined by the 95% global mixed criteria with an optical color change of bromothymol blue. Error valu...
Figure3.csv Sep 24, 2026 - Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells" Comma Separated Values - 1.1 KB - MD5: 9cbd1d1c9a0f2ad582952fc605584581 CSV file for Figure3: Here the measured viability and viable cell density (continuous line) of the single multi-compartment bioreactor (SMCB), the perfect Downscale system (pDs) and the reference are collected together with the corresponding cultivation time in days. Error values indicate the mean deviation of biological duplicates. Viable cell den...
Figure4.csv Sep 24, 2026 - Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells" Comma Separated Values - 591 B - MD5: ab3e09db3221855416be992875b3ebfe CSV file for Figure4: Here the growth rate μ per day with corresponding process time in days is presented. Error values indicate the mean deviation of biological duplicates. For the calculation, the viable cell density values were used and the growth rate was calculated for each day. The cultivations were performed in fed-batch mode in a 3-liter bi...
Figure5.csv Sep 24, 2026 - Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells" Comma Separated Values - 3.0 KB - MD5: a99d49c038b94483a2c1651be05340db CSV file for Figure5: Relevant process parameters such as Glucose, Lactate, Osmolality and monoclonal antibody concentration with corresponding process time in days. Errors indicate the mean deviation of biological duplicates. Glucose and lactate were measured with an automated enzymatic assay. Osmolality was measured by freeze-point determination...
Figure6.csv Sep 24, 2026 - Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells" Comma Separated Values - 1.5 KB - MD5: 4658ea2079bbc490268964e61e406d62 CSV file for Figure6: Here the cell-specific glucose consumption qS and cell-specific antibody production qP are depicted with the corresponding cultivation time. Error values indicate the mean deviation of biological duplicates. Values were calculated using the glucose concentration and antibody concentration change for each day divided by the cha...
Figure7.csv Sep 24, 2026 - Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells" Comma Separated Values - 803 B - MD5: 7caeb88e2d5e250cf93a4c140d369d90 CSV files for Figure7: Cell-specific antibody production qP values and corresponding growth rate μ per day. Error values indicate the mean deviation of biological duplicates. Values were calculated using the antibody concentration change for each day divided by the change in cell density. Antibody concentration was measured with a protein A HPLC me...
Figure8.csv Sep 24, 2026 - Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells" Comma Separated Values - 330 B - MD5: b30230e529ab94c5ff77536eadb01cd5 CSV file for Figurte8: Relative distribution of non-galactosylated and galactosylated glycoforms attached to asparagine as N-linked glycosylation. Abundance of product glycosylation was measured at the end of the cultivation after 12 days with HPLC involving an Amide column and a bicratic ammonium formicate gradient. Error values indicate the mean...

Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells"

Sep 24, 2026 - Mammalian Cell Culture

Barczyk, Jonas; Lopez medina, Barbara; Teleki, Attila; Satzer, Peter; Rautenbach, Ryan; Schlüter, Michael; Takors, Ralf, 2026, "Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells"", https://doi.org/10.18419/DARUS-6466, DaRUS, V1, UNF:6:lArxh/lys3TNx0/WEN5Rtg== [fileUNF]

Raw data for the manuscript “Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells”. The work explores two approaches of prolonged mixing time in laboratory-scale vessels without changing the power input. Experiments in 3 liter bioreactors were performed with NISTCHO...

All Data.xlsx

Sep 24, 2026 - Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells"

MS Excel Spreadsheet - 40.9 KB -

All Data Excel format: This MS Excel spreadsheet table contains all the tables described above just in xlsx format. Figure1 is missing because it is just an image and contains no scientific data.

Figure10.csv

Sep 24, 2026 - Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells"

Comma Separated Values - 2.5 KB -

CSV file for Figure10: Intracellular concentrations of key metabolites and amino acids are visible here with corresponding process time point of 5, 7, 9 and 11 days. Intracellular metabolite concentrations were determined in fmol/cell with HPLC coupled to a triple quadrupole mass spectrometer. Detected masses were confirmed with internal standards...

Figure2.csv

Sep 24, 2026 - Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells"

Comma Separated Values - 153 B -

Bioreactor mixing times of three bioreactor systems. The single multi-compartment bioreactor (SMCB), the perfect Downscale system (pDs) and the reference. All bioreactors were filled with 3.2 liters of 0.9% NaCl solution. The time in seconds was determined by the 95% global mixed criteria with an optical color change of bromothymol blue. Error valu...

Figure3.csv

Sep 24, 2026 - Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells"

Comma Separated Values - 1.1 KB -

CSV file for Figure3: Here the measured viability and viable cell density (continuous line) of the single multi-compartment bioreactor (SMCB), the perfect Downscale system (pDs) and the reference are collected together with the corresponding cultivation time in days. Error values indicate the mean deviation of biological duplicates. Viable cell den...

Figure4.csv

Sep 24, 2026 - Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells"

Comma Separated Values - 591 B -

CSV file for Figure4: Here the growth rate μ per day with corresponding process time in days is presented. Error values indicate the mean deviation of biological duplicates. For the calculation, the viable cell density values were used and the growth rate was calculated for each day. The cultivations were performed in fed-batch mode in a 3-liter bi...

Figure5.csv

Sep 24, 2026 - Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells"

Comma Separated Values - 3.0 KB -

CSV file for Figure5: Relevant process parameters such as Glucose, Lactate, Osmolality and monoclonal antibody concentration with corresponding process time in days. Errors indicate the mean deviation of biological duplicates. Glucose and lactate were measured with an automated enzymatic assay. Osmolality was measured by freeze-point determination...

Figure6.csv

Sep 24, 2026 - Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells"

Comma Separated Values - 1.5 KB -

CSV file for Figure6: Here the cell-specific glucose consumption qS and cell-specific antibody production qP are depicted with the corresponding cultivation time. Error values indicate the mean deviation of biological duplicates. Values were calculated using the glucose concentration and antibody concentration change for each day divided by the cha...

Figure7.csv

Sep 24, 2026 - Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells"

Comma Separated Values - 803 B -

CSV files for Figure7: Cell-specific antibody production qP values and corresponding growth rate μ per day. Error values indicate the mean deviation of biological duplicates. Values were calculated using the antibody concentration change for each day divided by the change in cell density. Antibody concentration was measured with a protein A HPLC me...

Figure8.csv

Sep 24, 2026 - Data for: "Scale-down bioreactors reveal that prolonged mixing times deteriorate the performance of antibody-producing Chinese hamster ovary cells"

Comma Separated Values - 330 B -

CSV file for Figurte8: Relative distribution of non-galactosylated and galactosylated glycoforms attached to asparagine as N-linked glycosylation. Abundance of product glycosylation was measured at the end of the cultivation after 12 days with HPLC involving an Amide column and a bicratic ammonium formicate gradient. Error values indicate the mean...

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