The fundamental understanding of droplet dynamics is the critical prerequisite to the prediction of natural processes and the optimization of technical systems. Many of these processes happen under extreme ambient conditions - e.g. high pressure or extreme temperatures - and can already be found in technical applications, despite the absence of fundamental knowledge. This is exactly where the new Collaborative Research Center focuses on. The goal is to gain a profound physical understanding of the essential processes. This understanding is the basis for new ways of analytical and numerical descriptions. Thereby, an improved prediction of large systems in nature or in technical applications shall be possible.