Department of Molecular Biochemistry

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801 to 810 of 850 Results

3B R661A 3.0 µM CN.txt Jun 18, 2020 - Deep enzymology data related to Dukatz et al.: Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase. Plain Text - 15.2 MB - MD5: eaffc720c83d51a0e58b16522c61838a
3B R823A 1.5 µM CN.txt Jun 18, 2020 - Deep enzymology data related to Dukatz et al.: Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase. Plain Text - 15.0 MB - MD5: 96ee894dbc6909dce97ae740b009936f
3B R823A 3.0 µM CN.txt Jun 18, 2020 - Deep enzymology data related to Dukatz et al.: Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase. Plain Text - 13.3 MB - MD5: b43754e5779e36d566d8361578ddc377
3B T775A 10 µM CN.txt Jun 18, 2020 - Deep enzymology data related to Dukatz et al.: Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase. Plain Text - 12.5 MB - MD5: cd6de1453f57c2d4bb3342947fb6bc34
3B T775A 5 µM CN.txt Jun 18, 2020 - Deep enzymology data related to Dukatz et al.: Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase. Plain Text - 11.2 MB - MD5: d42704b83063e6e40cae05a5cb076fb0
3B V657A 1 µM CN.txt Jun 18, 2020 - Deep enzymology data related to Dukatz et al.: Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase. Plain Text - 15.0 MB - MD5: fc2fcb757de4ed53040ddf013be25311
3B V657A 2 µM CN.txt Jun 18, 2020 - Deep enzymology data related to Dukatz et al.: Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase. Plain Text - 14.1 MB - MD5: c4c63430ab2a66e40753a1427c1a17c0
3B WT 0.5 µM CN.txt Jun 18, 2020 - Deep enzymology data related to Dukatz et al.: Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase. Plain Text - 16.9 MB - MD5: 1bcd220c1e7250d3a92ecc8705b0167b
3B WT 1.0 µM CN.txt Jun 18, 2020 - Deep enzymology data related to Dukatz et al.: Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase. Plain Text - 15.8 MB - MD5: a45369e148334f7c9fc784d9d890ccf5
Deep enzymology data related to Gao et al.: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms Jan 30, 2020 - Amplicon based bisulfite NGS data Jeltsch, Albert; Bashtrykov, Pavel; Emperle, Max; Adam, Sabrina; Dukatz, Michael, 2020, "Deep enzymology data related to Gao et al.: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms", https://doi.org/10.18419/DARUS-627, DaRUS, V1 Experimental procedures: Libraries of double stranded DNA substrates with CpG, CpH or CpN sites in randomized sequence context were methlyated by DNMT3A or DNMT3B. Reactions were stopped by shock freezing in liquid nitrogen, then treated with proteinase K for 2 hours. Afterwards, the DNA was digested with the BsaI-HFv2 enzyme and a hairpin was liga...

3B R661A 3.0 µM CN.txt

Jun 18, 2020 - Deep enzymology data related to Dukatz et al.: Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase.

Plain Text - 15.2 MB -

3B R823A 1.5 µM CN.txt

Jun 18, 2020 - Deep enzymology data related to Dukatz et al.: Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase.

Plain Text - 15.0 MB -

3B R823A 3.0 µM CN.txt

Jun 18, 2020 - Deep enzymology data related to Dukatz et al.: Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase.

Plain Text - 13.3 MB -

3B T775A 10 µM CN.txt

Jun 18, 2020 - Deep enzymology data related to Dukatz et al.: Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase.

Plain Text - 12.5 MB -

3B T775A 5 µM CN.txt

Jun 18, 2020 - Deep enzymology data related to Dukatz et al.: Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase.

Plain Text - 11.2 MB -

3B V657A 1 µM CN.txt

Jun 18, 2020 - Deep enzymology data related to Dukatz et al.: Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase.

Plain Text - 15.0 MB -

3B V657A 2 µM CN.txt

Jun 18, 2020 - Deep enzymology data related to Dukatz et al.: Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase.

Plain Text - 14.1 MB -

3B WT 0.5 µM CN.txt

Jun 18, 2020 - Deep enzymology data related to Dukatz et al.: Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase.

Plain Text - 16.9 MB -

3B WT 1.0 µM CN.txt

Jun 18, 2020 - Deep enzymology data related to Dukatz et al.: Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase.

Plain Text - 15.8 MB -

Deep enzymology data related to Gao et al.: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms

Jan 30, 2020 - Amplicon based bisulfite NGS data

Jeltsch, Albert; Bashtrykov, Pavel; Emperle, Max; Adam, Sabrina; Dukatz, Michael, 2020, "Deep enzymology data related to Gao et al.: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms", https://doi.org/10.18419/DARUS-627, DaRUS, V1

Experimental procedures: Libraries of double stranded DNA substrates with CpG, CpH or CpN sites in randomized sequence context were methlyated by DNMT3A or DNMT3B. Reactions were stopped by shock freezing in liquid nitrogen, then treated with proteinase K for 2 hours. Afterwards, the DNA was digested with the BsaI-HFv2 enzyme and a hairpin was liga...

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