GraphML file for homologues and reconstructed ancestors of arylsulfatases and phosphonate monoester hydrolaseshttps://doi.org/10.18419/darus-817Buchholz, Patrick C. F.DaRUS2021-05-032021-05-03T07:50:41ZProtein sequence network for homologues of arylsulfatases and phosphonate monoester hydrolases, including reconstructed ancestral sequences from a maximum-likelihood phylogenetic tree.Medicine, Health and Life Sciencesalignmentnetworkamino acid sequencegraphprotein sequenceEnglishPatrick C. F. Buchholz, Bert van Loo, Bernard D. G. Eenink, Erich Bornberg-Bauer, Jürgen Pleiss: "Ancestral sequences of a large promiscuous enzyme family correspond to bridges in sequence space in a network representation" (submitted)2021-05-03Buchholz, Patrick C. F.2020-07-01<a href="https://doi.org/10.18419/darus-1801">https://doi.org/10.18419/darus-1801</a>van Loo B, Schober M, Valkov E, Heberlein M, Bornberg-Bauer E, Faber K, et al. Structural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium melliloti: A Class I Sulfatase Specific for an Alkyl Sulfate Ester. J Mol Biol. 2018;430: 1004-1023. <a href="https://doi.org/10.1016/j.jmb.2018.02.010">doi:10.1016/j.jmb.2018.02.010</a>van Loo B, Bayer CD, Fischer G, Jonas S, Valkov E, Mohamed MF, et al. Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily. J Am Chem Soc. 2019;141: 370-387. <a href="https://doi.org/10.1021/jacs.8b10290">doi:10.1021/jacs.8b10290</a>CC BY 4.0