|
View: |
Part 1: Document Description
|
|
Citation |
|
|---|---|
|
Title: |
Protein sequences of arylsulfatases, phosphonate monoester hydrolases, and reconstructed ancestors |
|
Identification Number: |
doi:10.18419/darus-1801 |
|
Distributor: |
DaRUS |
|
Date of Distribution: |
2021-05-03 |
|
Version: |
1 |
|
Bibliographic Citation: |
Heberlein, Magdalena, 2021, "Protein sequences of arylsulfatases, phosphonate monoester hydrolases, and reconstructed ancestors", https://doi.org/10.18419/darus-1801, DaRUS, V1 |
|
Citation |
|
|
Title: |
Protein sequences of arylsulfatases, phosphonate monoester hydrolases, and reconstructed ancestors |
|
Identification Number: |
doi:10.18419/darus-1801 |
|
Authoring Entity: |
Heberlein, Magdalena |
|
Distributor: |
DaRUS |
|
Access Authority: |
Pleiss, Jürgen |
|
Depositor: |
Buchholz, Patrick C. F. |
|
Date of Deposit: |
2021-04-15 |
|
Holdings Information: |
https://doi.org/10.18419/darus-1801 |
|
Study Scope |
|
|
Keywords: |
Medicine, Health and Life Sciences, amino acid sequence, protein sequence, ancestor reconstruction, phylogeny |
|
Abstract: |
Protein sequences were derived from a maximum-likelihood phylogenetic tree for arylsulfatases and phosphonate monoester hydrolases, including a selection of reconstructed ancestral sequences. |
|
Notes: |
This dataset comprises 95 protein sequences annotated as homologues of arylsulfatases (AS) and 85 protein sequences annotated as homologues of phosphonate monoester hydrolases (PMH). In addition to these 180 protein sequences, 58 ancestral protein sequences were reconstructed from a maximum-likelihood phylogenetic tree ("node_"). |
|
Methodology and Processing |
|
|
Sources Statement |
|
|
Data Sources: |
van Loo B, Schober M, Valkov E, Heberlein M, Bornberg-Bauer E, Faber K, et al. "Structural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium melliloti: A Class I Sulfatase Specific for an Alkyl Sulfate Ester." J Mol Biol. 2018;430: 1004-1023. <a href="https://doi.org/10.1016/j.jmb.2018.02.010">doi:10.1016/j.jmb.2018.02.010</a> |
|
van Loo B, Bayer CD, Fischer G, Jonas S, Valkov E, Mohamed MF, et al. "Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily." J Am Chem Soc. 2019;141: 370-387. <a href="https://doi.org/10.1021/jacs.8b10290">doi:10.1021/jacs.8b10290</a> |
|
|
Heberlein M: "Evolution of substrate specificity in the alkaline phosphatase superfamily". Dissertation, Westfälische Wilhelms-Universität Münster, Germany, 2016 <a href="https://stg.ibs-bw.de/aDISWeb/app?service=direct/0/Home/$DirectLink&sp=SOPAC02&sp=SAKSWB-IdNr155480020X">https://stg.ibs-bw.de/aDISWeb/app?service=direct/0/Home/$DirectLink&sp=SOPAC02&sp=SAKSWB-IdNr155480020X</a> |
|
|
Data Access |
|
|
Other Study Description Materials |
|
|
Related Studies |
|
|
<a href="https://doi.org/10.18419/darus-817">https://doi.org/10.18419/darus-817</a> |
|
|
Related Publications |
|
|
Citation |
|
|
Title: |
Patrick C. F. Buchholz, Bert van Loo, Bernard D. G. Eenink, Erich Bornberg-Bauer, Jürgen Pleiss: "Ancestral sequences of a large promiscuous enzyme family correspond to bridges in sequence space in a network representation" (submitted) |
|
Bibliographic Citation: |
Patrick C. F. Buchholz, Bert van Loo, Bernard D. G. Eenink, Erich Bornberg-Bauer, Jürgen Pleiss: "Ancestral sequences of a large promiscuous enzyme family correspond to bridges in sequence space in a network representation" (submitted) |
|
Label: |
AS_PMH_ancestors.fasta |
|
Text: |
FASTA file for 238 protein sequences |
|
Notes: |
application/octet-stream |